In addition, laboratory parameters found in patients with severe SARS-CoV-2 infection, such as abnormally high levels of C-reactive protein, d-dimers, and ferritin, together with coagulopathy and hypoproteinemia are characteristic features of hyperinflammation known under the umbrella term of macrophage activation syndrome (MAS) or secondary hemophagocytic lymphohistiocytosis (HLH) (Cao 2020; McGonagle et al. 2020). This evidence concerns the gene CRP and macrophage activation syndrome.