Focusing on the role of secretory proteomes of the tumor as well as nontumor cells, including MSCs and PBMCs, that can be collected from cancer patients, this review described the counterintuitive generation procedure of iTSCs, a novel type of tumor-fighting cells, which produce atypical tumor-suppressing proteins such as Eno1, MSN, Ubc, Hsp90ab1, etc. Most of those proteins act as oncogenic intracellularly and as antioncogenic extracellularly, except for Calr. Here, ENO1 is linked to cancer.