In intron 2 of the SNCA gene in MSA patients, two CpG sites showed hypermethylation compared to controls: CpG-1 84 [77.75; 100]% vs. 77 [74; 79]%, p(U) = 0.001268; and CpG-2 100 [86; 100]% vs. 83 [81.5; 100]%, p(U) = 0.008788 (Figure 2). The gene discussed is SNCA; the disease is multiple system atrophy.