While the JAK2 I670V mutation has been reported at low frequency in the European population (https://gnomad.broadinstitute.org/ accessed on 3 October 2022), its exact impact on the pathogenesis of MDS may be arguable and further studies are recommended to investigate the relationship between JAK2 mutation variants and their clinico-morphologic phenotypes. This evidence concerns the gene JAK2 and myelodysplastic syndrome.