An aberrant iron metabolism and severe lipid peroxidation trigger ferroptosis, an iron-dependent kind of controlled cell death that results in OS and cell death (Fig. 3).101 It was also found to be involved in DA neuron death in PD.102 The enzyme acyl-CoA synthetase long-chain family member 4 (ACSL4) converts coenzyme A (CoA) to free polyunsaturated fatty acids (PUFA) in the cytosol. Here, ACSL4 is linked to Parkinson disease.