While transgenic PD mice do not exhibit overt degenerative pathology in dopaminergic neurons, functional abnormalities are present in their nigrostriatal system.200 Of the mouse models available, only the mouse prion promoter A53T α-synuclein transgenic mice (MitoPark) recapitulated the full range of α-synuclein pathology observed in humans.200–203 These MitoPark mice are thus particularly promising as PD models. Here, SNCA is linked to Parkinson disease.