APOE and Stroke: Recent studies have highlighted other risk factors for cognitive decline in post-stroke patients, such as education, occupation, recurrent stroke, PSD, post-stroke apathy, APOE ε4 status, infarcted volume in strategic areas (e.g., cortical limbic areas and heteromodal associative areas, including the frontal cortex and WM), and the presence of multiple lesions (e.g., [90,91,92,93,94]).