LEP and metabolic disease: The role of disorganisation of the circadian system in the mechanisms of metabolic disorders is confirmed by the data on the capability of resveratrol to abolish 11-week high-fat diet-induced circadian desynchrony and ameliorate the impaired lipid profiles, the plasma leptin rhythmities in mice that, as we suggest, can be associated with its impact on the expression of clock genes (BMAL1, CLOCK, and PER2) and clock-controlled lipid metabolism-related genes (SIRT1, PPARα, SREBP-1c, ACC1, and FAS) [41].