Additionally, IHC analysis of the Caspase7 and MFN2 expression levels in tumor cells of xenografts revealed that the miR-17-5p group exhibited lower levels of Caspase7 and MFN2 than the negative control group, which indicated that there was less apoptosis in the miR-17-5p group, and MFN2 was downregulated by miR-17-5p; however, these effects were abolished by overexpressing METTL14 (Fig. 6K). The gene discussed is MFN2; the disease is neoplasm.