Depletion of YTHDF1 suppresses the translation of lysosomal cathepsins in DCs, downregulated cathepsins attenuates antigen degradation and thus enhances cross-presentation to CD8 + T cells, further increased IFN-γ expression in CD8 + T cells upregulates PD-L1 expression in tumor cells [137]. Here, CTSS is linked to neoplasm.