METTL3 could upregulate NIFK-AS1, and NIFK-AS1 suppressed the expression of drug transporters Organic anion-transporting polypeptide 1B (OATP1B1) and OATP1B3 to inhibit sorafenib uptake, thus desensitize HCC cells. The gene discussed is METTL3; the disease is hepatocellular carcinoma.