R-2-hydroxyglutarate (R-2HG) inhibits progression of AML in vitro an in vivo through inhibiting FTO, synergizing with a series of first-line chemotherapy agents such as all-trans retinoic acid (ATRA), Azacitidine, Decitabine, and Daunorubicin [86]. This evidence concerns the gene FTO and acute myeloid leukemia.