(4) A mutation in E3 ligase adaptor SPOP (speckle type BTB/POZ protein) promotes the initiation and progression of prostate cancer through SQSTM1(Sequestosome-1)/p62-dependent autophagy and Nrf2(nuclear factor erythroid-2 related factor 2) activation [15]. The gene discussed is NFE2L2; the disease is Familial prostate cancer.