TNF and neoplasm: Importantly, IFN-γ+TNF-α+ CD8+ T cells were not present in unstimulated splenocytes from CR mice (CR No Stim) or in stimulated splenocytes from tumor-naive control mice (Naive + AH1) (Figure 8F), indicating the presence of a tumor antigen–specific CD8+ T cell memory pool in spleens of CR mice.