Using multiplex immunoassays, we examined type I IFN (IFN-α, IFN-β), type II IFN (IFN-γ), proinflammatory cytokine (GM-CSF, IL-6, IL-12p70), and proinflammatory chemokine (CXCL10 [IP-10], CCL2 [MCP-1], CCL3 [MIP-1α], CCL5 [RANTES]) signaling in the tumor microenvironment (TME). This evidence concerns the gene IL6 and neoplasm.