Notably, restoration of H3K36me3 in JHRCC12 through retroviral transduction of SETD2ΔN suppressed apoptosis triggered by inactivation of ASF1A/B or SUPT16H as well as CBL0137 treatment (29), supporting a critical role of histone chaperons in the tumor suppressor function of SETD2 across different cancer types. Here, SUPT16H is linked to neoplasm.