SETD2 and nonpapillary renal cell carcinoma: To determine whether the conserved sequence at the intron 5 of human ETV1 also contains an enhancer that is regulated by SETD2, ChIP-qPCR was performed on a patient-derived ccRCC cell line JHRCC12 that harbors a truncating mutation of SETD2 at the SRI domain (p.E2531*) (37).