KRAS and liver cancer: Gene set enrichment analysis (GSEA) revealed upregulation of several oncogenic pathways upon SETD2 loss, including the KRAS transcriptional signature, the PTEN-loss transcriptional signature, and PRC2-repressed targets identified in liver cancer (20), and malignant peripheral nerve sheath tumors (MPNST) (21) (Figure 2A and Supplemental Table 1).