INS and Insulin resistance: In full support that butyrate does not ameliorate metabolic health in DIO mice (Figure 5, B–G), FMT from butyrate-treated obese donors did not affect BW and fat mass (Figure 6B), food intake (Figure 6C), or markers related to insulin resistance, including fasting plasma glucose, insulin, and HOMA-IR, in recipient mice compared with FMT from control donors (Figure 6, D–F).