For example, a V620I substitution (exon 12, G858A) in TRPV4 is responsible for moderate brachyolmia, which exhibits short stature, scoliosis, and delayed development of deformed bones (Kang et al., 2012; Rock et al., 2008; Kang, 2012). This evidence concerns the gene TRPV4 and brachyolmia.