As a result, we speculate that due to the overlying of other abnormal genes, some cyst‐lining cells of MCRN-LMP on the basis of VHL gene abnormality, further proliferate to form solid expansive nodules, and then develop into ccRCC with cystic component similar to MCRN-LMP. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.