According to previous related studies [10, 11, 21, 22], we speculate that the low grade ccRCC with cystic component similar to MCRN-LMP through cyst-dependent pathway may be prone to degeneration or regression due to the lack of some key molecular alterations for overall tumor progression, and the specific mechanism needs to be further studied. The gene discussed is PDLIM7; the disease is nonpapillary renal cell carcinoma.