As shown in Fig. 1d, patients with severe/critical COVID-19 had higher titers of anti-IFN-γ autoAbs (median, 5.01 U/ml, IQR 0.44–18.93 U/ml) than non-severe COVID-19 patients (1.33 U/ml, IQR 0.06–8.05 U/ml, p = 0.11) or HC subjects (0.44 U/ml, IQR 0.04–8.66U/ml, p <0.05). Here, IFNG is linked to COVID-19.