IFNG and infection: Thus, the neutralizing anti-IFN-γ autoAbs are recognized as a cause of adult-onset immunodeficiency (AOID) and associated with increased risks of infection such as disseminated nontuberculous mycobacteria (NTM), non-typhoid Salmonella, Cryptococcus, and varicella-zoster virus (VZV), particularly in Asian populations [3–9].