In a recent study of systemic lupus erythematosus (SLE), the circGARS/miR-19a signaling pathway was shown to regulate the expression of YTHDF2 to alter the activation of the immune response, which was mediated by tumor necrosis factor alpha-induced protein 3 (TNFAIP3) [119]. The gene discussed is YTHDF2; the disease is systemic lupus erythematosus.