Finally, recurrent loss of chromosome 22q11 (which encompasses SMARCB1) has been reported in up to 55% of T-cell prolymphocytic leukemias (T-PLL) (combined N = 34), but SMARCB1 may not be significantly downregulated in the affected cases [168, 169]. Here, SMARCB1 is linked to T-cell prolymphocytic leukemia.