SMARCD2 and Sezary syndrome: Other SWI/SNF genes recurrently altered in CTCLs are SMARCE1 and SMARCD2 (each amplified in 20% Sézary syndrome patients, N = 25), ARID2 (deleted in 8% Sézary syndrome patients, N = 25), and SMARCB1 (point mutation frequency ~ 3%, combined N = 433) [112, 152–154, 156].