On the other hand, Brady et al. identified as candidate B-ALL drivers ARID2 (2.5% genetic alteration frequency, N = 1428), ARID1A (< 1%), ACTB (< 1%), and BICRAL (< 1%), all of which harbored mostly truncating mutations [166]. The gene discussed is ACTB; the disease is precursor B-cell acute lymphoblastic leukemia.