In line with this functional diversity, as will be detailed later, genetic alterations in SWI/SNF subunits are highly recurrent in various hematological malignancies, such as DLBCL [7, 8, 82, 83], whereas they are extremely rare in others, such as AML (excluding the acute promyelocytic leukemia (APL) subtype) [51, 84]. Here, SMARCA1 is linked to acute promyelocytic leukemia.