There were also 5 KLF5K369Q-downregulated and NTZ-upregulated genes whose lower expression levels in human prostate cancers were also significantly associated with worse overall survival, including TMPRSS2, CALB1, SPOCK2, COL4A4, and COL4A3 (Fig. 6a). The gene discussed is TMPRSS2; the disease is Familial prostate cancer.