CD274 and non-small cell lung carcinoma: CheckMate 277 trial (NCT02477826, randomized, open-label, phase III, 2748 participants) evaluated Nivolumab or Nivolumab plus Ipilimumab, or Nivolumab in combination with platinum-doublet chemotherapy to platinum doublet chemotherapy in PD-L1-defined previously untreated NSCLC [169].