Subsequently, KEYNOTE-010 (NCT01905657, randomized, phase II/III study, 1034 participants) compared the dosage gradient of Pembrolizumab with a fixed dose of docetaxel in patients who were pre-treated with advanced NSCLC (expressing PD-L1 ≥ 1%), keeping OS and PFS as the primary endpoints. This evidence concerns the gene CD274 and non-small cell lung carcinoma.