However, a study by Sumiyoshi et al. reported that 13 VHL variants were found in 12 of 56 patients with ccRCC (21.6%) with a median variant frequency of 0.78%, while only eight out of 28 patients (28.6%) had plasma VHL variants with VHL mutations in tumor tissue. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.