CASP8 and gastric cancer: Gu et al., 2005, reported that aspirin causes apoptosis in gastric cancer via changing Bcl2 associated X protein (BAX) conformation, moving BAX to the mitochondria, and activating caspase 8 (CASP8)/BH3 Interacting Domain Death Agonist (Bid) and caspase 3 (CASP3) [21].