TP53 and hepatocellular carcinoma: On the other side, the noticed high decrease in p53 level in the HCC group mostly favors the survival of cancerous cells and encourages cancer mass expansion [45], as evidenced by our histopathological findings concerning untreated HCC liver sections; hepatocytes were of disturbed organization with dense trabeculae, they showed pleomorphism, nonuniform eosinophilia of the cytoplasm with high N/C ratio, infiltrates, fibrosis, and neovascularization (Fig. 6B).