Previous literatures indicate critical role between Wnt and EGFR signaling convergence in cancer progression [41, 42], yet handful of them investigated the mechanistic role of dishevelled proteins in regulating EGFR signaling in breast cancer [43, 44] and none reported the mechanistic and functional effects of DVL2 modulation in HER2+ breast cancer. The gene discussed is EGFR; the disease is breast cancer.