Although reduction in cell confluence and/or proliferation was not significant between NTC vs. shDVL2 in SKBR3 and between NTC + Nert vs. shDVL2 + Nert in BT474 till the end of the experimental time points, continual decrease in cell proliferation observed in shDVL2 + Nert vs. shDVL2 alone in both cell lines indicating possible additive effect against cancer cell proliferation with the combination of HER2 and DVL2 inhibition. This evidence concerns the gene ERBB2 and cancer.