Although reduction in cell confluence and/or proliferation was not significant between NTC vs. shDVL2 in SKBR3 and between NTC + Nert vs. shDVL2 + Nert in BT474 till the end of the experimental time points, continual decrease in cell proliferation observed in shDVL2 + Nert vs. shDVL2 alone in both cell lines indicating possible additive effect against cancer cell proliferation with the combination of HER2 and DVL2 inhibition. Here, DVL2 is linked to cancer.