Interestingly, we found a significant positive correlation between baseline DVL2 levels and NLR (rho = 0.58; p = 0.033), which is a poor prognostic indicator of breast cancer survival while there was a negative correlation between DVL2 and cytotoxic T-cell marker, CD8α at baseline (rho = − 0.67; p = 0.010). This evidence concerns the gene CD8A and breast carcinoma.