Of note, there was a trend of significant positive correlation between baseline DVL2 and TIL score post NAC, and a trend of significant negative correlation between baseline CD8α and post NAC TIL score (Supplementary Table 6) depicting complex interaction between DVL2 and immune cell population in response to NAC in HER2+ breast cancer which requires more detailed investigation. Here, ERBB2 is linked to breast carcinoma.