Additionally, activation of distinct tumor intrinsic pathways such as, the Wnt/β-catenin pathway is associated with an immune-cold tumor TME and low TIL infiltration in melanoma and colorectal cancer [20–22] while high levels of stromal TIL infiltration were found to be correlated with β-catenin overexpression in breast cancer, raising the question of involvement of Wnt/β-catenin/DVL signaling cascades in tumor immune-surveillance and anti-tumor immune response. This evidence concerns the gene DVL1 and breast cancer.