BDNF and schizophrenia: At the neurochemical and molecular level, recent studies have shown that RHA rats present alterations of pre-/post-synaptic markers and trophic factors in the PFC and/or HPC, such as neuregulin1, homer1, synaptophysin, brain-derived neurotrophic factor (BDNF), and others, that have been linked with glutamatergic dysfunction, PFC maturation and schizophrenia [136] (reviewed by Fernandez-Teruel et al., [115]).