TNF and Sepsis: Furthermore, the percentage of DCs expressing MHC-II, CD80, and CD86, the level of mRNA expression of IL-12 and TNF-α by DCs, and the level of DC-mediated T-cell proliferation was all decreased, both in vivo and in vitro, when PINK1 was knocked out, suggesting that PINK1 knockout prevented the function of DCs during sepsis.