Future studies will attempt to further verify the protective role of ALT-100 mAb in NASH progression by using the AMLN68 and CDA-HFD-induced NASH mice model.69 Second, we only studied a select number of inflammation- and fibrosis-related genes/proteins which proved to be significantly dysregulated in IL-6, Ang-2, IL-1RA, TNFα, and SNAI1 in plasma/liver tissues. This evidence concerns the gene ANGPT2 and metabolic dysfunction-associated steatohepatitis.