NR1H4 and Familial prostate cancer: Many of the immune response related (e.g., IRF8, JAK3, PTGER4, RELB, IFITM3) and part of the lipid metabolism related genes (e.g., NR1H4, PPARGC1B, PLIN1, HSD17B14) were identified to be adaptive which addressed their significance for prostate cancer.