Our study confirmed alteration of known prostate cancer related pathways such as steroid metabolism (e.g., ABCA1, AKR1C3, UGT2B15, UGT2B17) and epithelial/endothelial cell proliferation and apoptotic process (e.g., CDK6, SNAI2, THBS1, TNFAIP3, EAF2, ATOH8) upon AR regulation and castration resistance. Here, CDK6 is linked to Familial prostate cancer.