Thus, the current study is designed to investigate expression level of SIRT3, SIRT4, SIRT5 and associated genes SOD1, SOD2, OGG1-2α, PARP1, GDH and HIF1α in glioma patients and to find out whether this expressional deregulation effects the risk of glioma. The gene discussed is SIRT4; the disease is central nervous system cancer.