SIRT4 and central nervous system cancer: Significant down-regulated expression of SIRT4 (p = 0.033), SIRT5 (p<0.0001), GDH (p = 0.03), OGG1-2α (p<0.0001), SOD1 (p<0.0001) and SOD2 (p<0.0001) was observed in glioma patients compared to controls as shown in Fig 1A and 1C.