SIRT4 and central nervous system cancer: Survival analysis showed that deregulation of SIRT3 (p<0.0081; Fig 8A), SIRT4 (p<0.0381; Fig 8B), SIRT5 (p<0.0151; Fig 8C), GDH (p<0.0108; Fig 8F), OGG1-2α (p<0.05; Fig 8G), PARP1 (p<0.0270; Fig 8H) and HIF1α (p<0.0053; Fig 8I) was found associated with significant decrease survival of glioma patients as shown in Fig 8.