In case of SIRT3 (p = 0.0142) and HIF1α (p = 0.0385) significant upregulation was observed (Fig 1B and 1D) while non-significant upregulated expression was observed in PARP1 (p = 0.203) in glioma samples as compared to healthy samples. The gene discussed is SIRT3; the disease is central nervous system cancer.