Additionally, by microarray analysis, several inflammatory cytokines, such as Infγ, Tnf, and Il1β were downregulated in the TME, including colon tumor cells, immune cells, fibroblasts, and other cells, in the S100a4-Cre; Ext1f/f mice compared to those in the control mice. The gene discussed is IL1B; the disease is colonic neoplasm.