The ratio of myofibroblasts to Tomato-positive fibroblasts did not differ significantly between S100a4-Cre; Ext1f/f and control mice; however, the ratio of the myofibroblast area to tumor area was significantly reduced in the S100a4-Cre; Ext1f/f mice compared to the control mice (Fig 3D). Here, S100A4 is linked to neoplasm.