There were no significant differences in the number of cytotoxic T cells in the peri- and intra-tumor regions of S100a4-Cre; Ext1f/f and control mice; however, there was a tendency for the number of CD8α-positive cells in the tumors of the S100a4-Cre; Ext1f/f mice to be lower than that in the control mice (Fig 4B). This evidence concerns the gene CD8A and neoplasm.