CP and infection: The Cp subunit is 21-kDa, and consists of 183 amino acids split into 2 functional domains: the N-terminal (assembly) domain (1-140 aa) that mediates multimerization of Cp dimers into capsids and the C-terminal domain (CTD) that facilitates pgRNA packaging, reverse transcription, and encodes the nuclear localization signal (NLS) that targets HBV nucleocapsids to the nucleus to initiate infection (16, –, 18) (Fig. 1A).