CP and hepatocellular carcinoma: In this study, we applied both single dual-antibody immunofluorescence and live cell imaging to study the intracellular distribution of HBV Cp in Huh7 hepatocellular carcinoma cells, revealing that Cp distribution changes markedly over time, dependent on Cp’s ability to assemble capsids and the state of the cell cycle (see summary model in Fig. 7).