IL22 and acute respiratory distress syndrome: However, I3C decreased the expansion of Th17 RORγt +IL-17a+IL-22− cells in ARDS-induced RORcreAhrfl/fL mice, but there was not a significant difference in the Th17 RORγt +IL-17a+IL-22+ cells when comparing the RORcreAhrfl/fL+LPS group versus the RORcreAhrfl/fL+LPS+I3C group (Fig. 5F and G).