In the current study, we investigated the role of AhR activation by I3C on the Th17/Th22 axis by examining the roles of miRNAs as well as their involvement in the regulation of RORγt +IL-17a+ IL-22− and RORγt +IL-17a+IL-22+ Th17 cells and Th22 cells (IL-17a-IL-22+) during LPS-mediated ARDS. Here, AHR is linked to acute respiratory distress syndrome.