While all mice infected with either the wild-type strain or the tetO-ENT2/ent2Δ mutant in the absence of DOX succumbed to infection by day 18, there was no mortality among DOX-treated animals infected with the tetO-ENT2/ent2Δ mutant, confirming that ENT2 is required for C. albicans virulence in a mammalian host (P < 0.0001) (Fig. 5A). Here, SLC29A2 is linked to infection.