CLINT1 and infection: While all mice infected with either the wild-type, ent2Δ/ent2Δ plus ENT2/ENT2, or ent2Δ/ent2Δ plus ENTH/ENTH strains succumbed to infection by day 6, there was no mortality among animals infected with the ent2Δ/ent2Δ mutant, confirming that the ENTH domain is sufficient for C. albicans virulence in a mammalian host (P < 0.001) (Fig. 5B).