Also in this patient, immune checkpoint inhibition was recommended based on high TMB, although immune cell deconvolution suggested a protumoral tumour microenvironment characterized by higher proportions of Tregs and immunosuppressive M2 macrophages and fewer M1 macrophages, CD8‐positive T cells and T‐follicular helper cells (Fig. S4). The gene discussed is CD8A; the disease is neoplasm.