CTNNB1 and hepatocellular carcinoma: To circumvent the difficulty of targeting the β‐catenin signaling pathway itself in HCC, we instead used a human genome‐scale CRISPR‐Cas9 knockout (GeCKO) v2 library to identify genes that support the pathway.[17] We chose the CTNNB1 gene wild‐type (WT) HCC cell line Huh7 to avoid the abnormal activation of β‐catenin signaling caused by the gene mutations.