Cholesterol deficiency stimulates that transcription factor SREBP2, which in turn increases the expression of genes involved in the cholesterol biosynthesis pathway.[24] To evaluate whether this can promote β‐catenin p‐Ser184 and β‐catenin signaling, we treated HCC cells with methyl‐β‐cyclodextrin (M‐β‐CD) which depletes cholesterol.[25] Subsequent immunoblotting showed that M‐β‐CD treatment partially decreased the levels total and p‐S184 β‐catenin. The gene discussed is SREBF2; the disease is hyperinsulinemic hypoglycemia, familial, 4.