The highly conserved Wnt‐β‐catenin signaling pathway regulates embryonic development, hepatobiliary development and homeostasis, and the repair response to liver injury.[10] Abnormal Wnt‐β‐catenin signaling is also closely related to the development of many cancers.[11] In the absence of active WNT signaling, cytoplasmic β‐catenin is rapidly degraded by the “APC complex” that includes the adenomatous polyposis coli (APC) tumor suppressor protein, Axin, glycogen synthase kinase (GSK)‐3β, casein kinase Iα (CKIα) and the E3‐ubiquitin ligase β‐TrCP. Here, APC is linked to cancer.