Therefore, we sought to explore the effect of Ab‐TP‐MDNPs treatment in reversing vascular dysfunction, which is frequently observed in the brains of AD patients.[14, 26] First, we hypothesized that a significant reduction in hypoxia and ROS following Ab‐TP‐MDNPs treatment would help normalize VEGF expression in the brains of AD mice. The gene discussed is VEGFA; the disease is Alzheimer disease.