The ventricular lymphatic pathway within the brain is another significant route of Aβ and tau clearance and it is known to be compromised as AD progresses.[15, 16] The clearance of CSF through these perivascular spaces is driven via arterial pulsatility.[28] We have previously demonstrated high selectivity and reactivity of Ab‐TP‐MDNPs in the CSF of AD brains via MRI.[23] Given the effects on vascular perfusion and its selectivity in the CSF, we examined whether treatment with Ab‐TP‐MDNPs could assist in normalizing lymphatic function. This evidence concerns the gene MAPT and Alzheimer disease.