After 2 weeks of treatment with Ab‐TP‐MDNPs, levels of carbonic anhydrase 9 (CA9), a hypoxic marker, were reduced within the cortex by 38%, and the hippocampus by 65% (Figure 2B); consistent with Ab‐TP‐MDNPs‐targeted primary regions of AD pathology. This evidence concerns the gene CA9 and Alzheimer disease.