APOE and early-onset autosomal dominant Alzheimer disease: Additionally, studies investigating cerebrovascular haemodynamics should measure apolipoprotein‐E4 (APOE‐4) status, a genetic risk factor for Alzheimer's disease, which further accelerates age‐related changes in biomarkers of Alzheimer's disease in perimenopausal and postmenopausal women (Mishra et al., 2021).