Interestingly, we found individual differences in the expression of GFRA1 protein, i.e., the expression level of GFRA1 protein in tumor tissues of patients with metastatic GC was found to be significantly higher than that in tumor tissues of patients with only primary GC, whereas there was no significant difference between primary and metastatic niches or between GC tissues and adjacent normal mucosal tissues. This evidence concerns the gene GFRA1 and neoplasm.