Additionally, among the overlapping genes between migraine and headache with glycemic traits, five genes have previously been associated with migraine (THADA, EHMT2, AMBRA1, and SMG6) (Hautakangas et al. 2022) and headache (ATG13) (Meng et al. 2018); now, these genes are also implicated in glycemic traits. This evidence concerns the gene SMG6 and Headache.