Several other genes (CISD2, NFKB1, SLC9B1/2, BDH2, and CENPE) in this region (± 500 kb) have been strongly associated with essential hypertension (Malik et al. 2015), inflammatory diseases, and autoimmune disorders (Lagou et al. 2021); these conditions are significant risk factors for migraine and glycemic traits like hyperglycaemia and IR. The gene discussed is CISD2; the disease is essential hypertension.