Additionally, KCNK16 and KCNK17 variants were associated with a higher risk of epilepsy as they altered channel currents and spike frequencies (Lee et al. 2021) which is noteworthy given epilepsy is more prevalent in migraine patients than in the general population, and the prevalence of migraine in epilepsy patients is higher than in non-epilepsy controls (Keezer et al. 2015) and migraine and epilepsy have been shown to have a shared genetic etiology (Anttila et al. 2018). This evidence concerns the gene KCNK16 and epilepsy.