EHMT2 and Headache: Furthermore, five of the 30 genome-wide significant genes overlapping migraine and more than one glycemic trait were the nearest genes to a lead migraine SNP (THADA, EHMT2, AMBRA1, and SMG6) (Hautakangas et al. 2022) and headache SNP (ATG13) (Meng et al. 2018).