INS and type 2 diabetes mellitus: Reduced expression of the KCNK16 gene has been suggested to play a role in beta-cell function and was strongly associated with altered insulin secretion (Ndiaye et al. 2017) and discovered as a susceptibility locus for T2D in several GWAS studies conducted in East Asian, Indian, and European descent populations (Cho et al. 2011; Wood et al. 2017).