In terms of potential pathophysiology, among these shared loci, we highlight five interesting loci of MANBA, KCNK16, ADAMTS9, NBEAL1, and ELFN1. MANBA, a novel locus shared by migraine and FG (lead SNP rs223482), headache and FG (lead SNP: rs223482), and headache and glucose (lead SNP rs223497) in the cross-trait meta-analyses. The gene discussed is ADAMTS9; the disease is Headache.