Aberrant expression of the classical cell–cell adhesion molecule P-cadherin (P-cad; encoded by the CDH3 gene, referred to here as P-cad) has been associated with aggressive tumor behavior in breast, gastric, prostate, pancreatic, bladder and colorectal carcinomas, among others (Vieira and Paredes, 2015). The gene discussed is CDH3; the disease is colorectal carcinoma.