MRTFA and breast carcinoma: Thus, during the early stage of breast cancer, major alterations to the actin cytoskeleton could control signaling pathways through distinct mechanisms: an increase in F-actin assembly would induce signaling pathways, such as MRTF-A–SRF, while actomyosin activity would trigger the mechanical induction of signaling components, such as ERK and SRC, highlighting the key contribution of actin cytoskeleton regulation to carcinogenesis.