Consistent with a role for MRTF-A–SRF signaling in mediating P-cad functional effects in fully transformed cells, MRTF-A/SRF has been shown to play an important role in the metastatic lung colonization of breast cancer cells and in drug resistance of basal cell carcinoma (Medjkane et al., 2009; Whitson et al., 2018). The gene discussed is CDH3; the disease is basal cell carcinoma.