By performing network analysis, we found that PRRT2 had the highest degree of connectivity (D = 16) and betweenness centrality (CB = 0.37) in this network, making it the most topologically important node, and central hub in the epilepsy subnetwork of 16p11.2dup/+ mice (Fig. 4i). The gene discussed is PRRT2; the disease is epilepsy.