Our findings uncover four key aspects in the regulation of sleep: (1) SREBP levels are altered in Cyfip mutant flies; (2) SREBP activity on wakefulness genes such as malic enzyme regulates night-time sleep onset and amount; (3) the NADP+/NADPH are regulated by the SREBP/Men axis; (4) specific modulations of this metabolic pathway ameliorate the observed sleep deficits (Figs. 4, 5) suggesting this pathway could be explored for the development of sleep disorder treatments. Here, ELL is linked to sleep disorder.