We note that PIK3CA double mutations are relatively more dominant in BRCA, IDC (Breast Invasive Ductal Carcinoma), ILC (Breast Invasive Lobular Carcinoma), COAD, and UEC (Uterine Endometrioid Carcinoma) subtypes (Fig. 2b). This evidence concerns the gene LMNA and invasive ductal breast carcinoma.