Lu et al. assessed the impact of Müller-Gärtner (MG) and iterative Yang (IY) PVC on 11C-UCB-J brain PET images for finding synaptic vesicle glycoprotein 2A (SV2A), which has been suggested as an indicator of synaptic density in Alzheimer’s disease (AD) [18]. This evidence concerns the gene SV2A and early-onset autosomal dominant Alzheimer disease.