PTEN and cardiac arrest: Pharmacological PTEN inhibition attenuates apoptosis of hypoxic cardiomyocytes in vitro, improves isolated rat heart functional recovery after I/R, reduces infarct size after in vivo myocardial infarction, and improves survival and cardiac energetic recovery after in vivo mouse cardiac arrest (Keyes et al., 2010; Li et al., 2015; Zhu et al., 2014, 2021).