In the isolated rat heart, administration of okadaic acid (PP2A inhibitor) or MG‐132 (proteasome inhibitor) attenuated ischemia‐induced PTEN degradation under normothermic conditions (Cai & Semenza, 2005), raising the question of whether the TH preserves PTEN expression through inhibition of PP2A‐ or proteasome‐dependent mechanisms. The gene discussed is PTEN; the disease is ischemia.