These results diverge from preclinical in vivo cardiac arrest studies in which cooling to 30–34°C during CPR or shortly after return of spontaneous circulation were associated with enhanced post‐reperfusion Akt phosphorylation in the heart and brain (Beiser et al., 2010; Hsu et al., 2009; Jahandiez et al., 2019; Li et al., 2019). The gene discussed is AKT1; the disease is cardiac arrest.