A dual role for β‐catenin in both insulin‐ and exercise‐induced glucose uptake (Masson et al., 2021), coupled with the findings reported here that insulin resistance is associated with lower levels of skeletal muscle β‐catenin is somewhat incongruent with the observation that many insulin‐resistant individuals exhibit normal exercise‐stimulated glucose uptake (Kennedy et al., 1999; King et al., 1993; Kingwell et al., 2002; Wojtaszewski et al., 1999). The gene discussed is INS; the disease is Insulin resistance.