STUB1 and early-onset autosomal dominant Alzheimer disease: In addition to its implication on the risk of hematologic malignancy, the importance of CHIP in the neurological field is rapidly increasing as CHIP increases the risk of major cardiovascular events including ischemic stroke,12, 13, 14, 15, 16, 17, 18, 19, 20, 21 while its unexpected protective role on Alzheimer's disease (AD) was also reported.22