IL10 and breast carcinoma: Matrix‐produced NO activates pro‐cancer signaling pathways of estrogen receptor (ER)‐negative breast cancer cells and induces white blood cells to synthesize transforming growth factor beta (TGF‐β) and interleukin 10 (IL‐10), which have immunosuppressive effects50 and iNOS is a powerful predictive marker of poor prognosis.50