At present, it is unknown why these EMRN patients exhibit anti‐NGL antibodies and therefore the detailed molecular mechanisms need to be clarified further, although the aforementioned studies on GM2 gangliosidosis and Gaucher disease suggest that excess amounts of respective glycolipids may be a strong inducer for the development of autoantibodies against these glycolipids in the respective disorders. This evidence concerns the gene ERBB2 and Gaucher disease.