The protein promotes glioma cell proliferation,50 the number of Ki67+ aberrant astrocytes increased significantly in an amyotrophic lateral sclerosis (ALS) rat model,51 and WNT5a protein expression was upregulated in the spinal cord of ALS patients,52 These results suggest that the increase in aberrant astrocytes in ALS may be related to the increased expression of WNT5a. This evidence concerns the gene WNT5A and amyotrophic lateral sclerosis.