Taken together, these results demonstrated that the improved tumor control in Tipe2ΔNK/ΔNK mice was mediated by both T‐bet and Eomes‐dependent NK cell effector functions, suggesting that TIPE2 deficiency in NK cells might unleash CD8+ T cell‐dependent antitumor immunity by increasing the effector functions of NK cells through promoting the activity of T‐bet and Eomes. The gene discussed is EOMES; the disease is neoplasm.