For example, tumor cell‐expressed TIPE2 has been reported to suppress tumor growth.[36, 37, 38] Furthermore, hydrodynamic gene delivery of TIPE2 results in the activation of antitumor immunity, including the activation of NK cells.[36] Since the approach of hydrodynamic gene delivery causes gene expression mainly in liver parenchymal cells (hepatocytes),[39, 40] the study suggests that hydrodynamic gene delivery of TIPE2 might indirectly activate the antitumor immune response via overexpressing TIPE2 in nonimmune cells. This evidence concerns the gene TIPE2 and neoplasm.