More importantly, depletion of CD8+ T cells by anti‐CD8 monoclonal antibodies also compromised the tumor‐suppressing effects of NK‐specific TIPE2 deficiency in Tipe2ΔNK/ΔNK mice (Figure 2D), indicating that CD8+ T cells were also required for the improved antitumor response in Tipe2ΔNK/ΔNK mice, suggesting that Tipe2 deletion in NK cells might indirectly promote the antitumor CD8+ T cell response. Here, TIPE2 is linked to neoplasm.